SkinCeuticals P-TIOX Anti-Wrinkle Peptide Serum (1 fl. oz.)
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$148.00
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
P-TIOX is a peptide-powered serum clinically proven to reduce the appearance of 9 types of expression lines and reveal glass skin radiance. Inspired by the effects of neurotoxin injections, P-TIOX features a patent-pending blend of advanced peptides amplified by synergistic actives (PHA, Niacinamide, and Laminaria Extract) to visibly reduce wrinkles, improve skin texture and radiance, and complement the results of professional injectables.
P-TIOX is physician-tested to complement neurotoxin injections and is effective on its own to achieve needle-free wrinkle correction without the aid of professional injectables.
What is a Neurotoxin:
Muscular tissue facilitates movement, whether voluntary or involuntary. There are over two dozen facial muscles, which contract to produce expressions such as smiles, frowns, and brow movement. As we age, important structural proteins like collagen and elastin degrade and become less pliable. Over time, the combination of muscle movement and changes in the structure and integrity of the skin can lead to fine and deep expression lines. Neurotoxin injections are a popular in-office treatment used to treat expression wrinkles caused by muscle contractions. When injected, neurotoxins work by temporarily blocking the signals between muscles and nerves to limit contractions, soften expression lines, and prevent the formation of new wrinkles. Results from this treatment are typically seen two weeks post treatment and last around three months.
While neurotoxin injections are the industry standard for reducing expression lines, some areas of the face are difficult to inject.
When paired together, P-TIOX and neurotoxin injections work synergistically to help reduce the appearance of wrinkles, targeting areas of the face that neurotoxins alone don't treat, and delivering fast, long-lasting results.
Clinical Proof:
In 1 Week:
Visibly improves skin smoothness, refines the look of pores, and reveals glass skin radiance
In 12 Weeks:
- Reduces the appearance of 9 types of expression lines, even those neurotoxin injections do not treat:
- Nasolabial folds (smile lines)
- Forehead wrinkles
- Glabellar wrinkles (the 11's)
- Crow's feet
- Cheek folds
- Marionette lines
- Dynamic under-eye wrinkles
- Inter-ocular lines (bunny lines)
- Global fine lines
- Reduces the appearance of global fine lines by 20.6%
Additional Benefits:
- Hydrates skin up to 24 hours after application
- Improves skin barrier with 1 application
- Reveals glass skin radiance in 1 week of use.
- Physician-tested to complement neurotoxin injections.
- Suitable for all skin types and tones.
Key Ingredients:
- Advanced Peptide Complex (2% Hexapeptide + 2% Dipeptide): Known to help reduce the appearance of contraction lines.
- 5% PHA: A gentle chemical exfoliant to help improve skin texture and enhance skin radiance.
- 5% Niacinamide: Strengthens the skin's moisture barrier and reduces the appearance of discoloration.
- 1% Laminaria Extract: Known to hydrate, soothe skin, and improve wrinkle correction.
SEE OUR PROTOCOL:
A 12-week, single center clinical study was conducted on 82 females with Fitzpatrick type I-VI, (52% of subjects with sensitive skin), ages 34-65 and mild to moderate wrinkles, fine lines, pore appearance, rough skin texture evaluated by dermatologist. Efficacy evaluations were conducted at baseline, week 1, week 2, week 4, week 8 and week 12.
Once or twice daily, apply 4-6 drops to the palm of the hand and dab onto the forehead, cheeks, and chin. Blend the product into the skin. If using in the morning, apply after a SkinCeuticals antioxidant and before a SkinCeuticals moisturizer and sunscreen. If using in the evening, apply before a corrective cream or retinol. If layering corrective serums, it is recommended to apply products from thinnest to thickest.
Aqua / Water / Eau, Niacinamide, Gluconolactone, Butylene Glycol, Peg/Ppg/Polybutylene Glycol-8/5/3 Glycerin, Alcohol Denat., Pentylene Glycol, Methyl Gluceth-20, Glycerin, Potassium Hydroxide, Hydroxyethylcellulose, Salicylic Acid, Chlorphenesin, Phytic Acid, Adenosine, Sodium Benzoate, Laminaria Digitata Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetyl Hexapeptide-8.
For the latest information, it is recommended to review the ingredient list printed on the packaging of the product prior to usage or consumption.
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Frequently Bought Together

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SkinCeuticals P-TIOX Anti-Wrinkle Peptide Serum (1 fl. oz.)
$148.00
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Top Customer Reviews
Reviews and results may vary from person to person. Customer reviews are and do not represent the views of The Hut Group.
So Far My Skin is Improved
I have been using this for about 3 months and so far have seen improvement in the clarity of my skin. I just recently added CE Ferulic to see if I will get an added benefit.
by JudiBB Verified Purchase
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Worth a try
This didn’t do great things for my skin but I can see it making a difference for others if they don’t already use Botox.
by Jenn
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Maybe
I am on my second bottle. I have not noticed an improvement. I will continue to use it because I use several of their other products and believe in the science of skinceuticals. No scent, easy to apply.
by Skin101 Verified Purchase
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Awesome prosuct
I have tried many wrinkle creams and finally, this one delivers. It goes on like water, doesn’t smell and absorbs quickly. You have to use it morning and evening to achieve the desired results. I need a gallon size bottle of this magic potion!!
by Opinionshmo Verified Purchase
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Love all things SC
This was a great add to my skincare routine. I think it’s great that it compliments my treatments
by LaurDet20 Verified Purchase
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Holy Cow
Listen. I am the laziest person when it comes to product reviews. I never write them. But this stuff deserves one. I am honestly shocked at how much my skin has improved over the span of 3 days. Fine lines are getting smoother, my smile lines are less pronounced, and my skin is just brighter overall. Glowing even. The best part? My forehead is smooth and shiny. SHINY! Like it was when I was 20. Like I’ve just received a fresh batch of Botox. I’m thrilled every time I look in the mirror. This stuff is the real deal and worth every penny.
by CS
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Impressive
I am 62 years old with fair skin and fine lines and wrinkles. I have been using this about 3 times/week for about 2 months. It’s slight but I am seeing some improvement in the lines under my eyes. I am going to continue to use.
by Amby Verified Purchase
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Amazing serum
I’m really glad I tried P Tiox. This serum is not sticky at all and gives your skin a nice drink. It glides over skin but absorbs quickly. I have noticed the pores on my nose are invisible. I have been using everyday for 3 weeks. Really recommend.
by Suzanne Verified Purchase
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the A’s “PLUS SIGN”
Botox or any good filler may give you the “A” you were looking for; but, this stuff here is the plus sign you want to go with that A! This little bottle bumps up any score! Even an A to an A+ !!!!!
by Barnhonkey Verified Purchase
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No Botox necessary!
I had been contemplating Botox, but decided to try this instead and it has been amazing! My 11s look so much better after 2 weeks and I’m stunned!
by No Botox for me! Verified Purchase
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