UP TO 30% OFF WITH CODE JOY + Spend $300+ & Get a FREE Best of Dermstore Kit. SHOP NOW
FREE US Shipping $50+ Ask an Expert Dermstore Rewards Refer a Friend, Get $25
iS Clinical

iS Clinical Active Serum (1 oz.)

A multi-tasking face serum that improves the appearance of aging, acne-prone and dull complexions.

Rewards members earn 710 points on this order

Join Dermstore Rewards

$142.00

Or 4 interest free payments of $35.50 with afterpay


In stock | Usually dispatched within 24 hours


Delivery & Returns
Free delivery is available on all orders over $50. Please see our shipping information page for all available delivery options.
If I'm not completely happy with my item?
Please see our returns policy.
*points earned on final checkout price, after any applied discounts.

Frequently Bought Together

iS Clinical Active Serum (1 oz.)

This item

iS Clinical Active Serum (1 oz.)

$142.00

Total Price:

$230.00

Other Customers Bought

Customer Reviews

4.64

513 reviews

5

4

3

2

1

414

46

30

11

12

Top Customer Reviews

Reviews and results may vary from person to person. Customer reviews are and do not represent the views of The Hut Group.

I LOVE this serum!

It is the perfect all around serum. I use it every night for anti-aging and prevents breakouts. It's seriously amazing for everything. It's not greasy at all and you can feel it working after you put it on.

by Anonymous Verified Purchase

Was this helpful?

Changed my skin within 3 days!

I always struggled with blackheads on my nose and slight redness on my cheeks and within a week of using iS Clinical serum I noticed instantly my blackheads had practically diminished and my skin tone became more even. I would also get a cystic zit once a month and after using this I have yet to have one! The serum also helped with evening out my combination skin. I use 4-5 drops morning and night. I now get away with just wearing under eye concealer and powder! Best product I have bought from Dermstore!

by Anonymous Verified Purchase

Was this helpful?

Blackheads, Meet Your Match!

The line between tingling and burning is a fine one, but a hard one. I learned this the hard way with Drunk Elephant C-Firma Day Serum. I wanted it to work so badly because the reviews were off the charts. I wanted to believe that what I felt was tingling, but it was not... iS Active Serum has a legitimate and delightful tingle, like the feeling in your mouth after you pop spearmint gum! I would never compare this to a burning sensation. If it feels that way, rinse it off with a GENTLE cleanser and apply either a antimicrobial gel, or Cortizone 10 Anti-Itch Ointment. My doctor told me about Cortizone 10 Anti-Itch Ointment after a retinol burn. The white Cortizone cream contains alcohol so ensure it is the ointment (Vaseline consistency). Works like a charm! I have light, combo, sensitive skin but I have built up a BHA tolerance. I have used Paula's Choice 2% Liquid Exfoliant every night for two years. It takes time to build up tolerance to it, maybe 2-weeks to a month, but it is pretty gentle so it didn't take long. Overtime I added Paula's 9% BHA once a week all over, on top of my barrier night cream. I loved Paula's 2% and saw a difference when I didn't use it. However, it never purged my pores, just lightened them from black to a light grey. With iS Active Serum my skin is purging a bit. All the little bumps, milia, blackheads and gunk deep in my skin is starting to come up. I have had one tiny milia by my eye for a year, but it turns out it was a deep, hard blackhead! Paula's Choice kept it from growing but never got it to come up or out. I am overly cautious with extractions so unless it is ready to pop, I won't touch it. Even then, I will use Mario Badescu Drying Lotion and let it purge itself. Scars are forever! I think Paula's Choice is a great starter BHA, and without it my skin may not have tolerated this. I think the SD Alcohol 30 in the iS Active Serum is the ticket. People are cautious with alcohol because it breaks the barrier, but in my case I needed that. It opens the barrier just enough to let the magic penetrate just below the surface. Sometimes alcohol can be helpful for people with acne, milia, and pervasive, deep, stubborn blackheads. Manual exfoliation is too abrasive. Extractions, even proper ones, can leave marks if the gunk isn't close enough to the surface, and sticking a needle in a pore or pimple is just a terrible idea. Products like Paula's Choice are gentle, but they only moderately manage surface issues. iS Active Serum allows the actives to permeate deep enough into the skin to lift out the gunk. I will be mindful of the SD Alcohol 30, and use it sparingly once my skin is all cleared out. I will also ensure I use a strong barrier repair cream (I like SkinCeuticals Triple Lipid Restore 2:4:2 for winter because I tend to be dry and it is recommended for anyone who consistently uses BHAs since they disrupt the barrier even if they don't contain alcohol). Otherwise, I think for the first time in 30 years I won't dread magnifying mirrors or morning, sunlit cuddles with my boyfriend.

by Anonymous

Was this helpful?

Doe snot break me out

Great serum that is light weight and hydrating. it does not break me out. I have seen less wrinkles since it keeps my face so hydrated

by Anonymous

Was this helpful?

Great serum!

This serum is awesome and does live up to all its promises. My skin texture has improved, as well as I would occasionally have acne and that is gone too. It really brightens nicely.

by Anonymous Verified Purchase

Was this helpful?

The only thing that's worked to keep my skin clear!

Having battled adult onset acne for the last 8 years, I've tried a lot of different skin care routines to help. I was doing hydra facials once a month but the cost was just too much to maintain. My esthetician suggested iS active serum and I've been hooked ever since!

by Jenna Verified Purchase

Was this helpful?

Best serum ever!!!

I am so in love with this serum. 6 months after ResurFX, this serum has helped me maintain my skin looking beautiful. I love the tingly and cooling sensation. My skin looks so glowy! I use it every other night, since it's a little bit pricey but a little goes a long way. Totally life changer.

by Anonymous Verified Purchase

Was this helpful?

Made a Difference

My skin texture is definitely smoother and breakouts have minimized. I'm really happy that blackheads are not as problematic as they were prior to use.

by Anonymous

Was this helpful?

Excellent!

I've only used this for a little over a week, but I can tell you that I have no new breakouts since using it, and my skin seems far less textured. I have sensitive, acne prone, sometimes combo/oily skin and this has agreed with my skin beautifully! I use the IS Clinical cleansing complex as well. These make a great team-what a fabulous skincare line!!

by Anonymous Verified Purchase

Was this helpful?

Life Saver

IS clinical is slowly taking all of my money.. i started with the cleanser, im now on my second bottle after falling in love with that i took the plunge and finally bought the active serum, the cleanser cleared up 90% of my acne, with a retinol l twice a week. the feeling of this alone is so amazing and refreshing.. but the results are even better, my deep stubborn acne on my chin and around my nose was brought up to the surface and dried by the next morning, any black heads were able to be extracted with little to no pressure. and the 'glowing texture' came about a week later after applying twice a day. i used to have a million different brands in my medicine cabinet but now i have 4 products, cleansing complex, a retinol, my active serum and a hydrating moisturizer and my skin has never been clearer. LOOOOVE. also, from some people stating below that the dropper is a waste of product isnt using it correctly i use about 5 drops in my palm and rub them together and pat on my face and neck and get all product on my face.

by Anonymous Verified Purchase

Was this helpful?